Uses/Indications: Tramadol is a synthetic codeine analogue and a weak μ opioid receptor agonist. Tramadol also inhibits neuronal reuptake of norepinephrine and serotonin and may facilitate serotonin release. Therefore, it is recommended for acute and chronic pain and may be used alone to treat mild pain or adjunctively in a multimodal
Uses/Indications: Amantadine may have efficacy and clinical usefulness against some veterinary viral diseases, but presently the greatest interest for its use in small animals is as an NMDA antagonist in the adjunctive treatment of chronic pain, particularly those tolerant to opioids. Amantadine antagonizes the N-methyl-D-aspartate (NMDA) receptor, and chronic pain
Uses/Indications: Treatment of chemotherapy induced nausea and vomiting (CINV), anorexia, associated with renal failure (azotemia), congestive heart failure, gastrointestinal disorders, liver disease, or neoplasia. Studies/Case Reports: For years, veterinarians have used B-vitamins and steroids for appetite stimulation in canines and benzodiazepines in felines. Pharmacy faculty at The Mississippi State College of
Amitriptyline is one of the most widely used tricyclic antidepressants (TCAs) in companion animal behavioral medicine, exerting antihistaminic, anti-inflammatory, analgesic, and antidepressant effects. It increases synaptic activity of serotonin and norepinephrine, has significant central and peripheral anticholinergic activity, and stimulates β-adrenergic receptors in smooth muscle (e.g. the bladder), causing a
Historically, prednisone and prednisolone have been considered therapeutically equivalent when used in veterinary medicine, however studies prove otherwise. Although found equivalent in humans and canines, feline and equine dosing is considerably different. In a study by Rosser and Graham-Mize, feline were administered a 10mg total dose of either prednisone or
Spraying is a common feline behavioral problem, most often in males, and it is one of the most frequent reasons why cats end up in pet shelters. To prevent this annoying behavior from happening, many owners should consider treatment. A study performed in 2001, at the University of California-Davis, showed
Tired of scratches, hunting for, wrestling, and cleaning up after your kitty every time you give her thyroid medication? If kitty does not like taking pills and suspensions she is not alone. You might be happy to learn there is an easier way!! Her hyperthyroid medication, methimazole, can be compounded
Uses/Indications: Controlling phosphate levels and preventing or reversing secondary hyperparathyroidism in dogs and cats suffering with chronic renal failure (CRF). Studies: A salutary effect of calcitriol treatment of CRF was shown in a placebo-controlled study of 37 dogs. The dose of calcitriol was adjusted according to serial ionized calcium and PTH determinations,
Uses/Indications: Treatment of hypertension (HTN) in felines (systolic blood pressure > 160mm Hg), which is typically secondary to other diseases (renal failure, cardiac causes, such as thyrotoxic cardiomyopathy or primary hypertrophic cardiomyopathy, etc.) and is most often seen in middle-aged or geriatric cats. These cats typically present with acute symptoms
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