Although only approved for human use, Gabapentin is widely used in veterinary medicine for both neuroleptic and analgesic indications, and has become a valuable adjunct in veterinary therapies. Gabapentin was available as a scored 100mg tablet allowing for some small animal dosing, however this dosage form has been discontinued leaving only 100mg capsules and Neurontin® [...]
Historically, prednisone and prednisolone have been considered therapeutically equivalent when used in veterinary medicine, however studies prove otherwise. Although found equivalent in humans and canines, feline and equine dosing is considerably different. In a study by Rosser and Graham-Mize, feline were administered a 10mg total dose of either prednisone or prednisolone to determine comparative pharmacokinetics [...]
Ocular administration of cyclopsorin (CsA) is frequently used as treatment for keratoconjunctivitis sicca (KCS) in canines. Cyclosporin is an immunosuppressive drug that reverses immune-mediated destruction of the lacrimal glands. A study performed by Izci et al. determined that topical administration of a 2% solution of CsA was effective for the treatment of dogs with KCS. [...]
Mitotane is primarily used for the treatment of pituitary-dependent hyperadrenocorticism (PDH) and in the palliative care of adrenal carcinoma, primarily in canines. It works by causing severe, progressive necrosis of the zona fasciculata and zona reticularis within days of starting therapy.1 Typically, hyperadrenocorticism is most commonly seen in middle-age to older dogs (7-12 years old) [...]
Spraying is a common feline behavioral problem, most often in males, and it is one of the most frequent reasons why cats end up in pet shelters. To prevent this annoying behavior from happening, many owners should consider treatment. A study performed in 2001, at the University of California-Davis, showed the effectiveness of fluoxetine, a [...]
Tired of scratches, hunting for, wrestling, and cleaning up after your kitty every time you give her thyroid medication? If kitty does not like taking pills and suspensions she is not alone. You might be happy to learn there is an easier way!! Her hyperthyroid medication, methimazole, can be compounded into a topical preparation by [...]
Enrofloxacin is a broad-spectrum, concentration-dependent*, bactericidal antibiotic used in a wide variety of species. A fluroquinolone, it is believed to act by inhibiting bacteria DNA-gyrase preventing DNA supercoiling and synthesis. Enrofloxacin has demonstrated a significant post-antibiotic effect (PAE)** for both gram – and + bacteria including Pseudomonas aeruginosa, Klebsiella spp., E coli, Enterobacter, Campylobacter, Shigella, [...]
Uses/Indications: Controlling phosphate levels and preventing or reversing secondary hyperparathyroidism in dogs and cats suffering with chronic renal failure (CRF). Studies: A salutary effect of calcitriol treatment of CRF was shown in a placebo-controlled study of 37 dogs. The dose of calcitriol was adjusted according to serial ionized calcium and PTH determinations, and ranged from [...]
Uses/Indications: Treatment of Pulmonary Arterial Hypertension in canines (PAH) (pulmonary arterial systolic pressure > 30mm Hg, pulmonary arterial diastolic pressure > 15mm Hg, or mean pulmonary arterial pressure > 20mm Hg), is often associated with heartworm infection, respiratory conditions and acidosis. This is a life-threatening condition if untreated, ultimately causing right sided heart failure and [...]
Uses/Indications: Prevention or minimization of recurrence of aortic thromboembolism associated with heart diseases such as cardiomyopathy and mitral valve dysplasia. Studies: 1. In 2013, a large scale multi-center prospective randomized trial known as FAT-CAT (Feline Arterial Thromboembolism: Clopidogrel vs. Aspirin Trial) results were released determining clopidogrel offered longer survival rates when compared to aspirin in [...]
