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TOPICAL HAIR LOSS

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Hair Loss

Shedding hair is a natural and even healthy occurrence – people typically shed between 50 and 100 single hairs each day. However, there is a natural balance to the process of shedding hair and when the balance is disrupted – meaning more hair is falling out than growing back in – this can result in hair loss. While most hair loss is due to hereditary causes, it can also be the result of hormonal changes, medical conditions, environmental factors, stress, trauma, alopecia, pregnancy, or even a normal part of aging. 

Androgenetic alopecia is the most common cause of hair loss. This kind of hair loss is caused by genetics and hormonal imbalances, and presents differently in men and women. For men, this type of hair loss usually begins above the temples and continues upward, eventually resulting in baldness. For women with this type of hair loss, hair gradually things across the entire scalp and can become very thin; however, the hairline doesn’t typically recede.

The Hair Growth Cycle

The hair follicle undergoes a cyclic growth pattern that consists of phases of active growth and elongation of the hair shaft, followed by periods of rest and regression triggered by apoptotic signals. Apoptosis is a process wherein the body deploys a mechanism to eliminate unnecessary or anomalous cells through a sequence of molecular events, eventually leading to the demise of the cell. Hair follicles go through this process, and the cycle can be categorized into three distinct phases: anagen (growth), catagen (transition), and telogen (rest). In a normal, healthy scalp, approximately 80-90% of the hair is in the anagen phase, 10-20% is in the telogen phase, and only 1-2% is in the catagen phase.

Androgenetic alopecia (female/male pattern baldness) is the most common type of hair loss. This type of hair loss presents differently in men and women. Men can start to see this type of hair loss soon after they reach puberty, and it progresses over time. It is possible for men to eventually become completely bald. For women, however, this type of hair loss results in significant thinning of the hair, but rarely leads to complete baldness.

Anagen Effluvium is rapid hair loss triggered by medications and treatments such as chemotherapy that prevent hair follicle production, sometimes poisoning the follicle. Cancer medications are powerful and often effective in killing cancerous cells. However, as they attack all quickly forming cells, they tend to also stop hair follicle production. Once the medical treatment is completed, this type of hair loss is usually reversed. Once the treatment is complete, the hair follicles are usually restored and grow back on their own, though physicians can prescribe certain medication to speed up the process.

Telogen effluvium occurs when a significant number of follicles enter the telogen phase, but the anagen phase doesn’t begin. This type of hair loss is typically triggered by medical conditions or events such as fever, surgery, or childbirth, but may also be the result of vitamin or mineral deficiencies.

Tinea Capitis, also referred to as scalp ringworm, is caused by a fungal infection on the scalp. Though this condition is more commonly seen it children, it can affect adults as well. Tinea capitis causes hair to fall out in patches, resulting in bald spots that can increase in size over time. The affected areas typically exhibit red, scaly skin that can be itchy. Early treatment is crucial for tinea capitis, as it is highly contagious and can spread rapidly through contact with contaminated objects or skin. Treatment options include antifungal medication, medicated shampoo, and oral medication. With appropriate treatment, hair regrowth is possible.

Cicatricial alopecia, also known as scarring alopecia, is a rare type of hair loss that occurs when inflammation destroys hair follicles and scar tissue replaces them, preventing hair regrowth. This condition can result from a variety of causes, including autoimmune disorders, infections, trauma, and certain medications. The onset of cicatricial alopecia may be gradual, with symptoms going unnoticed. However, sudden hair loss can also occur. This hair loss subtype affects both genders and can occur at any age. Symptoms of this condition include itching, burning, and tenderness of the scalp, as well as hair loss that may be accompanied by redness, scaling, or pus-filled bumps. Early diagnosis and treatment are crucial to prevent further damage and preserve existing hair. Treatment options include topical and oral medications, injections, and in severe cases, hair transplant surgery.

Traction alopecia, also known as cosmetic hair damage, is a type of hair loss resulting from excessive tension and pulling on the hair – often from hairstyling and use of treatment. The constant pulling can damage the hair follicles, leading to hair loss that may be permanent if left untreated. Symptoms of traction alopecia include a receding hairline, thinning hair, and bald spots around the hairline and temples. Early intervention is essential to prevent further damage and promote hair regrowth. However, hair loss can become permanent if scarring develops. Treatment options include changing hairstyles to reduce tension on the hair, using hair growth products, and in severe cases, hair transplant surgery.

Causes of Hair Loss

Female/male pattern baldness, or androgenetic alopecia, a hereditary condition affecting up to 80% of men by the age of 80. Female pattern baldness tends to start more frequently during the reproductive years (age 25 to 40), and a second peak of cases is seen in menopausal women (age 50 to 60).

The root cause of both female and male pattern baldness is multifactorial. Some potential factors are:

Genetics: Genetic variations in the hair follicle receptor can cause the follicles to shrink over time. As a result, hair growth becomes shorter and thinner, eventually leading to a cessation of new hair growth. 

Hormones: A drop in estrogen and progesterone levels slows down hair growth and makes it thinner. This decrease also causes an increase in androgen production, which are male hormones. Androgens make hair follicles smaller, leading to hair loss on the head.

Medication: Cancer treatment is the most common, but the use of beta-blockers, blood thinners, antidepressants, cholesterol-lowering drugs, certain NSAIDS, and hormone related drugs can all result in hair loss. 

Age: Cell growth begins to slow down as the body ages. As a result, cell growth in the hair follicles also slows, which can lead to the rate of cell death becoming quicker than the rate of cell growth.

Stress: Stress chemicals such as cortisol deter the normal activity of hair follicles, as the body reserves its energy for vital functions. Both short-term and chronic stress can send hair follicles into the “resting” phase, preventing new growth.

Hair Styles & Treatments: Tight hair styles such as cornrows, weaves, twists, and tight ponytail put intense pressure on the hair roots which can damage the follicles. This can potentially result in scarring and permanent hair loss.

Treating Hair Loss

One of the most commonly used and recognized hair-regrowth ingredients is Minoxidil. Other active ingredients widely prescribed are compounds of estrogen and progesterone for individuals who may be experiencing hair loss due to hormonal depletion or changes. The following medications are offered by Pharmacy Solutions, and can be customized and compounded to suit the needs of each patient. These medications come in several forms, such as creams, gels, and shampoos.According to the National Library of Medicine:

Saw Palmetto nourishes the hair follicle to promote normal growth
Zinc Sulfate adds shine, strength and density to hair
Niacinimide -0.5% activates dormant hair follicles, reduces hair fall and help reverse effects of DHT on hair growth cycle
Ketoconazole is an antifungal known for increasing the size of hair follicles and increasing hair growth – similar to minoxidol 
Biotin – 0.03% naturally stimulates the scalp to promote hair growth
Estradiol increases hair count and thickness
Fluocinonide is a steroid to reduce inflammation
Azelaic Acid reduces DHT levels and slows down hair loss
Caffeine – 1% blocks effect of DHT in male hair follicles – stimulates hair shaft elongation
Progesterone – helps keep hair in the Anagen phase (growing phase) – keeps hair on your head longer
Spironolactone – 1.247% helps combat conditions that cause hair loss like PCOS
Green Tea inhibits the activity of hormones that induces hair loss
CoQ10 boosts Keratin which depletes with aging
Zinc Oxide counteract the effects of DHT
• Minoxidil prolongs the anagen (growth) phase
• Latanoprost prolongs the anagen (growth) phase
Finasteride reduces DHT levels, thus slowing down hair loss
Salicylic Acid can help control DHT. A recent study found a hair loss shampoo containing 0.2% salicylic acid increased growth in people with hair loss by over 17% (Kim, 2022).

Compounded Medication for Hair Loss

While hair loss can be a very dreaded, disheartening experience, Pharmacy Solutions is equipped with a variety of different hair loss treatments that can help to regrow hair as well as prevent balding and hair thinning. Our pharmacists tailor medications for every patient with every hair loss need. Compounding pharmacies are advised for individuals suffering from hair loss rather than over-the-counter generic medications. Compounding pharmacists are able to customize and personalize various different treatment types that range from topical medications to foams and soaps.

In addition to PLENTY and RIZN for men, Pharmacy Solutions exclusively offers Triple Combo, the most anticipated treatment for hair loss since minoxidil alone. Our optimal triple combination, patented, fixed-dose therapy of Minoxidil, Finasteride, and Latanoprost work synergistically to stop hair loss and induce hair regrowth. The clinical study results were positive and show the performance of the triple combination hair loss prescription to be 4x more effective than Minoxidil alone and 2x more effective than Finasteride alone. For more on the science behind the patent, please visit TripleHair.ca

Here at Pharmacy Solutions, we tailor every formulation to be unique to the patient, effective, and efficient. Patients are advised to use topical solutions compounded with various active ingredients; treatments may be available in lotion, soaps, foams, and topical creams. To learn more about our compounded treatments for hair loss and regrowth, don’t hesitate to contact us.

VIEW OUR TOP HAIR LOSS COMPOUNDED FORMULAS HERE.

References

authors, All, and Richard L. Lin. “Systemic Causes of Hair Loss.” Taylor & Francis, 5 May 2016, https://www.tandfonline.com/doi/full/10.1080/07853890.2016.1180426.
“Hair Loss in Women: Causes, Treatment & Prevention.” Cleveland Clinic, https://my.clevelandclinic.org/health/diseases/16921-hair-loss-in-women.
“Hair Loss.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 26 Mar. 2022, https://www.mayoclinic.org/diseases-conditions/hair-loss/symptoms-causes/syc-20372926#:~:text=It%20can%20be%20the%20result,most%20common%20cause%20of%20baldness.
“How Stress Causes Hair Loss.” National Institutes of Health, U.S. Department of Health and Human Services, 20 Apr. 2021, https://www.nih.gov/news-events/nih-research-matters/how-stress-causes-hair-loss.
Nestor, Mark S, et al. “Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics.” Journal of Cosmetic Dermatology, U.S. National Library of Medicine, Dec. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298335/.
Qi, Ji, and Luis A Garza. “An Overview of Alopecias.” Cold Spring Harbor Perspectives in Medicine, U.S. National Library of Medicine, 1 Mar. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935391/.

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Pharmacy Solutions - RX Compound

Pharmacy Solutions
1921 W Pioneer Pkwy,
Arlington, TX 76013

Pharmacy Solutions - RX Compound

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