Chlorambucil is an alkylating antineoplastic medication that is used to treat many immune response disease states in animals. This medication can be very useful in treating both irritable bowel syndrome (IBD) and certain cancers like lymphosarcoma. Both conditions will present with similar clinical symptoms but a biopsy will confirm the
Chlorambucil is metabolized by the liver and well absorbed orally. It seems to be very well tolerated in comparison to other antineoplastic drugs. Side effects related to chlorambucil include bone marrow suppression, hepatotoxicity and GI distress. Adequate testing is recommended to monitor these potential side effects by testing CBC’s at baseline, after first month and at 3 months time. For proper handling of the drug and any elimination products from the animal, it is recommended wearing gloves. Pet owners must be stressed compliance with dosing to ensure best results in their animals.
Cat dosing of Chlorambucil
- 2mg every other day OR
- 15mg/m2 daily for 4 days ever 3 weeks
Kuipel, M., Pfent, C., Xie, Y., Xue, Y.G., et al. (2011). Diagnostic Algorithm to Differentiate Lymphoma From Inflammation in Female Small Intestinal Biopsy Samples. Veterinary Pathology, 48 (1), 212-222. https://doi.org/10.1177/0300985810389479