Uses/Indications: Amantadine may have efficacy and clinical usefulness against some veterinary viral diseases, but presently the greatest interest for its use in small animals is as an NMDA antagonist in the adjunctive treatment of chronic pain, particularly those tolerant to opioids. Amantadine antagonizes the N-methyl-D-aspartate (NMDA) receptor, and chronic pain
As a veterinary provider do you commonly see otitis externa in your canine patients? Does it become a continuous problem for many of your clients and their pets? If you face these questions in your practice, then we can definitely help you. Otitis can be caused by many factors such
Uses/Indications: Treatment of chemotherapy induced nausea and vomiting (CINV), anorexia, associated with renal failure (azotemia), congestive heart failure, gastrointestinal disorders, liver disease, or neoplasia. Studies/Case Reports: For years, veterinarians have used B-vitamins and steroids for appetite stimulation in canines and benzodiazepines in felines. Pharmacy faculty at The Mississippi State College of
Phenylpropanolamine (PPA), an α1-adrenergic receptor agonist, is often used in canines to help with urinary incontinence (urine leakage) by tightening the bladder sphincter muscle, most commonly occurring in middle-aged spayed female dogs. A study performed by Claeys, S. et al. performed a retrospective study to determine the efficacy of a
Amitriptyline is one of the most widely used tricyclic antidepressants (TCAs) in companion animal behavioral medicine, exerting antihistaminic, anti-inflammatory, analgesic, and antidepressant effects. It increases synaptic activity of serotonin and norepinephrine, has significant central and peripheral anticholinergic activity, and stimulates β-adrenergic receptors in smooth muscle (e.g. the bladder), causing a
Ocular administration of cyclopsorin (CsA) is frequently used as treatment for keratoconjunctivitis sicca (KCS) in canines. Cyclosporin is an immunosuppressive drug that reverses immune-mediated destruction of the lacrimal glands. A study performed by Izci et al. determined that topical administration of a 2% solution of CsA was effective for the
Mitotane is primarily used for the treatment of pituitary-dependent hyperadrenocorticism (PDH) and in the palliative care of adrenal carcinoma, primarily in canines. It works by causing severe, progressive necrosis of the zona fasciculata and zona reticularis within days of starting therapy.1 Typically, hyperadrenocorticism is most commonly seen in middle-age to older
Uses/Indications: Treatment of Pulmonary Arterial Hypertension in canines (PAH) (pulmonary arterial systolic pressure > 30mm Hg, pulmonary arterial diastolic pressure > 15mm Hg, or mean pulmonary arterial pressure > 20mm Hg), is often associated with heartworm infection, respiratory conditions and acidosis. This is a life-threatening condition if untreated, ultimately causing
Uses/Indications: Prevention or minimization of recurrence of aortic thromboembolism associated with heart diseases such as cardiomyopathy and mitral valve dysplasia. Studies: 1. In 2013, a large scale multi-center prospective randomized trial known as FAT-CAT (Feline Arterial Thromboembolism: Clopidogrel vs. Aspirin Trial) results were released determining clopidogrel offered longer survival rates when compared
Uses/Indications: Mostly used in estrogen responsive incontinence in spayed female dogs and in the medical treatment of benign prostatic hypertrophy in male dogs. Controversially, it has been used in the prevention of pregnancy after mismating in female dogs and cats. Studies: In a retrospective study, 40 ovariectomized dogs were divided
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