Mitotane is primarily used for the treatment of pituitary-dependent hyperadrenocorticism (PDH) and in the palliative care of adrenal carcinoma, primarily in canines. It works by causing severe, progressive necrosis of the zona fasciculata and zona reticularis within days of starting therapy.1 Typically, hyperadrenocorticism is most commonly seen in middle-age to older
Spraying is a common feline behavioral problem, most often in males, and it is one of the most frequent reasons why cats end up in pet shelters. To prevent this annoying behavior from happening, many owners should consider treatment. A study performed in 2001, at the University of California-Davis, showed
Tired of scratches, hunting for, wrestling, and cleaning up after your kitty every time you give her thyroid medication? If kitty does not like taking pills and suspensions she is not alone. You might be happy to learn there is an easier way!! Her hyperthyroid medication, methimazole, can be compounded
Enrofloxacin is a broad-spectrum, concentration-dependent*, bactericidal antibiotic used in a wide variety of species. A fluroquinolone, it is believed to act by inhibiting bacteria DNA-gyrase preventing DNA supercoiling and synthesis. Enrofloxacin has demonstrated a significant post-antibiotic effect (PAE)** for both gram – and + bacteria including Pseudomonas aeruginosa, Klebsiella spp., E
Uses/Indications: Controlling phosphate levels and preventing or reversing secondary hyperparathyroidism in dogs and cats suffering with chronic renal failure (CRF). Studies: A salutary effect of calcitriol treatment of CRF was shown in a placebo-controlled study of 37 dogs. The dose of calcitriol was adjusted according to serial ionized calcium and PTH determinations,
Uses/Indications: Treatment of Pulmonary Arterial Hypertension in canines (PAH) (pulmonary arterial systolic pressure > 30mm Hg, pulmonary arterial diastolic pressure > 15mm Hg, or mean pulmonary arterial pressure > 20mm Hg), is often associated with heartworm infection, respiratory conditions and acidosis. This is a life-threatening condition if untreated, ultimately causing
Uses/Indications: Prevention or minimization of recurrence of aortic thromboembolism associated with heart diseases such as cardiomyopathy and mitral valve dysplasia. Studies: 1. In 2013, a large scale multi-center prospective randomized trial known as FAT-CAT (Feline Arterial Thromboembolism: Clopidogrel vs. Aspirin Trial) results were released determining clopidogrel offered longer survival rates when compared
Uses/Indications: Mostly used in estrogen responsive incontinence in spayed female dogs and in the medical treatment of benign prostatic hypertrophy in male dogs. Controversially, it has been used in the prevention of pregnancy after mismating in female dogs and cats. Studies: In a retrospective study, 40 ovariectomized dogs were divided
Uses/Indications: Treatment of hypertension (HTN) in felines (systolic blood pressure > 160mm Hg), which is typically secondary to other diseases (renal failure, cardiac causes, such as thyrotoxic cardiomyopathy or primary hypertrophic cardiomyopathy, etc.) and is most often seen in middle-aged or geriatric cats. These cats typically present with acute symptoms
Uses/Indications: Used as both primary and adjunctive therapy to control seizures in dogs who are not adequately controlled on phenobarbital alone (when steady state trough phenobarbital concentrations are > 30mcg/ml for one month). Historically, it is only used alone when patients are suffering from phenobarbital hepatotoxicity, and occasionally may be
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